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This explains why one lorazepam dose, Inspite of its shorter serum 50 percent-everyday living, has extra prolonged peak results than an equivalent diazepam dose.[99] Lorazepam is promptly conjugated at its 3-hydroxy group into lorazepam glucuronide that's then excreted in the urine. Lorazepam glucuronide has no demonstrable CNS activity in animals.
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